The Intestinal Regulation of Gastric Emptying

A series of studies demonstrated how that the slowing of gastric emptying by fat and other means could reduce postprandial blood sugar, suppress blood alcohol levels, offering new mechanisms for treatment of diabetes and beating the breathalyzer. Further studies showed physiological adaptation to high fat diets, leading to a blunting of this effect.

  1. McFarlane, A., Pooley, L., Welch, I.McL., Rumsey, R.D.E. and Read, N.W. (1986) How does dietary lipid lower blood alcohol levels? Gut 27: 15-18.
  2. Read, N.W., Welch, I.McL., Austen, C.J., Barnish, C., Bartlett, C.E., Baxter, A.J., Brown, C., Compton, M.E., Hume, K.E., Storie, I. and Worlding, J. (1986) Swallowing food without chewing. A simple way to reduce postprandial glycaemia. Br. J. Nutr. 55: 43-47
  3. Welch, I.McL., Bruce, C., Hill, S.E., Read, N.W. (1987) Duodenal and ileal lipid suppresses postprandial blood glucose and insulin responses in man: possible implications for the dietary management of diabetes mellitus. Clin. Sci. Mol. Med. 72: 209-216.
  4. Welch, I.McL., Cunningham, K.M., Read, N.W. (1988) Regulation of Gastric Emptying by Ileal Nutrients in Humans. Gastroenterology 94: 401-404.
  5. Eyre-Brook, I., Read, N.W., Brownson, J., Johnson, A.G. (1988) Influence of intraduodenal chenodeoxycholic acid on fasting secretory and pressure activity in the stomach and duodenum. J. Gastroenterol. Hepatol. 3: 557-563.
  6. Read, N.W., Houghton, L.A. (1989) Gastric emptying. In; Motility Disorders, Ed. A. Ouyang, Gastroenterol. Clin. N. America 18: 359.
  7. Cunningham, K., Read, N.W (1989). The effect of incorporating fat into different components of a meal on gastric emptying and postprandial blood glucose and insulin responses. British Journal of Nutrition; 61(2): 285-290.
  8. Houghton, L.A., Kerrigan, D., Read, N.W. (1990) Effect of intraduodenal infusion of acid on the antro-pyloroduodenal motor unit in human volunteers. J. GI Motility 2 (3): 202-208.
  9. Houghton, L.A., Mangnall, Y.F., Read, N.W. (1990) Effect of incorporating fat into a liquid test meal on the relation between intragastric distribution and gastric emptying in human volunteers. Gut 31: 1226-1229.
  10. Cunningham, K.M., Daly, J., Horowitz, M., Read, N.W. (1991) Gastrointestinal adaptation to diets of differing fat composition in human volunteers. Gut 32: 483-486.