Disturbed gastroduodenal motility in duodenal ulcer patients

A series of studies conducted by Mr David Kerrigan and using the Dent sleeve demonstrated that acid can get trapped in the duodenal bulb in patients predisposed to duodenal ulceration. This can be prevented by drugs that induce gastroduodenal peristalsis.

  1. Houghton, L.A., Kerrigan, D., Read, N.W. (1990) Effect of intraduodenal infusion of acid on the antro-pyloroduodenal motor unit in human volunteers. J. GI Motility 2 (3): 202-208.
  2. Kerrigan, D.D., Read, N.W., Taylor, M.E., Houghton, L.A., Johnson, A.G. (1989) Duodenal bulb acidity and the natural history of duodenal ulceration. Lancet. (8th July). 2(8654):61-3.
  3. Kerrigan, D.D., Houghton, L.A., Read, N.W., Johnson, A.G., Taylor, M.E. (1991) Disturbed gastroduodenal motility in patients with active and healed duodenal ulceration. Gastroenterology 100 (4): 892-900.
  4. Kerrigan, D.D., Taylor, M.E., Read, N.W., Johnson, A.G. (1993) Acid motility and ulcers: a comparison of cisapride with placebo in the prevention of duodenal ulcer relapse. Gut 1993; 34: 1042-1046.