The intestinal regulation of eating behaviour

Having shown that intestinal infusion of lipid will delay gastric emptying, probably by the release of CCK, we were interested to find out whether it would inhibit eating behaviour. The discovery that it did and was more potent than isoenergetic quantities of carbohydrate initiated a new area of research. Further studies revealed that the intestinal mechanisms regulating eating behaviour by lipid could be blunted by high fat diets, suggesting that physiological toleration of fat could contribute to obesity. Psychological needs could, however, override physiological control.

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