A model to study colonic fermentation

Don't imagine that medical research is a glamorous profession. Dr Christine Edwards spent three years in our department devising a continuous anaerobic culture of human faeces, by which she could study the fermentation of carbohydrate. Her determination earned her a PhD and ultimately a Professorship. Where there's muck, there's...... Read more »

Food and mood

We had been investigating the effects of intestinal infusions of lipid on small bowel transit times in rats when we observed that animals that received the lipid tended to fall asleep. We wondered whether this might explain why people tend to feel drowsy after a rich meal and irritable after... Read more »

The intestinal regulation of eating behaviour

Having shown that intestinal infusion of lipid will delay gastric emptying, probably by the release of CCK, we were interested to find out whether it would inhibit eating behaviour. The discovery that it did and was more potent than isoenergetic quantities of carbohydrate initiated a new area of research. ... Read more »