Nick Read » stress

Despatches from Derbyshire Ice Field (2)

Nick Read — Sat, 04 Dec 2010 06:40:13 +0000

0610 GMT 04/12/10

Minus 15 with precipitation! Visibility 200 yards. Ice!

Transport held fast. Frost forming on rigging.

Troops down in mouth. Fog freezing on beards! Try to encourage. ‘Chin up!’ But supplies low. Half rations. Last banana. No brandy. Fear mutiny.

If no improvement, will try dash to base camp tomorrow

Scott, i/c expedition.

Despatches from Derbyshire Ice Field (1) 0755 GMT 2.12.10. Snow flurries overnight but pressure rising. Blizzard...
Despatches from Derbyshire Ice Field (3) 0645 GMT 07/12/10 Successful expedition. Grytviken basking in balmy zero. ...
People watching; their lives in their faces. A troupe of black musicians with southern accents and...

Emotional upset determines the persistence of gastroenteritis after the infection has gone

admin — Sun, 01 Mar 2009 09:22:31 +0000

About 10% of people develop persistent diarrhoea after an attack of gastroenteritis even though there is no evidence of an infective agent. Studies conducted by Dr Kok-Ann Gwee in collaboration with Drs Mike McKendrick and Professor Steve Collins from McMaster University in Ontario revealed that anxiety, depression and life trauma occurring at the time of the original infection predicted persistence of symptoms and inflammation. It was as if the gastroenteritis were recruited to express unresolved emotional issues. Further studies showed that the same principle applied to surgical trauma such as hysterectomy, and to infections in other parts of the body. Symptoms caused by psychological stress were likely to persist as long as the stress persisted.

Gwee, K.A., Graham, J.C., McKendrick, M.W., Collins, S.M., Marshall, J.S., Walters, S.J., Read, N.W. (1996). Psychometric scores and persistence of Irritable Bowel after infectious diarrhoea. The Lancet. Jan 20;347(8995):150-3.
Gwee KA, Leong YL, Graham C, McKendrick M, Collins SM, Walters SH. Underwood JE. Read NW. (1999). The role of psychological and biological factors in post infective gut dysfunction. Gut. 44: 400-406.
Gwee KA. Collins SF and Read NW. (2000) Increased rectal mucosal expression of interleukin lB as a marker of inflammatory pathogenesis in recently acquired post infectious IBS. 2000.
Lewis IM, Read NW, McKendrick MW (2003). Prospective study of factors influencing the persistence of symptoms in hospitalised patients with acute infection. Journal of Psychosomatic Research. 2003; 54 (4): 307-311

IBS, recurrent dyspepsia or gastritis caused by emotional tension? I have been suffering with gastro problems for about 4...
Rectal Sensitivity Irritable Bowel Syndome (IBS) is characterized by increased sensitivity of...
Psychological influences on the gut The opportunity to retrain as a psychoanalytical psychotherapist sharpened my...

Small Intestinal Transit and Motility

admin — Sun, 01 Mar 2009 08:56:12 +0000

A collaboration with Dr Immanuel Bergman from the Safety in Mines Research Establishment in Sheffield led to the development of a simple device for measuring breath hydrogen, which we exploited for the measurement of small intestinal transit time. The combination of this with scintigraphic measurement of gastric emptying and radioopaque markers for colonic transit allowed us to track a single solid meal through the gastrointestinal tract in health and disease. Using this method we studied the effect of stress, diet, intestinal intubation, patterns of contraction and even rectal distension on intestinal transit; the relationship between transit and absorption and showed how disorders of transit related to symptom patterns in patients with Irritable Bowel Syndrome.

Cann, P.A., Read, N.W., Brown, C., Hobson, N., Holdsworth, C.D. (1983) The Irritable Bowel Syndrome (IBS) relationship of disorders in the transit of a single solid meal to symptom patterns. Gut 24: 405-411.
Cann, P.A., Read, N.W., Cammack, I., Childs, H., Holden, S., Kashman, R., Longmore, I., Nix, S., Simms, N., Swallow, K., Weller, J. (1983) Psychological stress and the passage of a standard meal through the stomach and small intestine in man. Gut 24: 236-240.
Read, N.W., Al-Janabi, M.N., Cann, P.A. (1984) Breath hydrogen and the pathogenesis of pneumatosis coli. Gut 25: 839-845.
Read, N.W., Al Janabi, M.N., Bates, T.E., Barber, D.C. (1983) The effect of gastrointestinal intubation on the passage of a solid meal through the stomach and small intestine in humans. Gastroenterology 84: 1568-1572.
Holgate, A.M., Read, N.W. (1983) The relationship between small bowel transit time and absorption of a solid meal: influence of metoclopramide, magnesium sulfate and lactulose. Dig. Dis. & Sci. 28: 812-819.
Read, N.W., Al-Janabi, M.N., Barber, D.C. and Edwards, C.A. (1984) The relationship between post-prandial motor activity in the human small intestine and the gastrointestinal transit of food. Gastroenterology 86: 721-727.
Youle, M.S., Read, N.W. (1985) The effect of painless rectal distension on gastrointestinal transit of a solid meal. Dig. Dis. Sci. 29: 902-906.
Read, N.W., Bates, T.E., Al-Janabi, M.N. and Cann, P.A. (1985) The interpretation of the breath hydrogen profile after a solid meal containing unabsorbable carbohydrate. Gut 26: 834-842.
Read, N.W., Al-Janabi, M.N., Holgate, A.M. and Barber, D.C. (1986) Simultaneous measurement of gastric emptying, small bowel residence and colonic filling of a solid meal by the use of the gamma camera. Gut 27: 300-308.

The Ileal Brake The observation that that infusion of fat and to a...
The intestinal regulation of eating behaviour Having shown that intestinal infusion of lipid will delay gastric...
The Intestinal Regulation of Gastric Emptying A series of studies demonstrated how that the slowing of...

Rectal Sensitivity

admin — Sun, 01 Mar 2009 08:32:53 +0000

Irritable Bowel Syndome (IBS) is characterized by increased sensitivity of the rectum. We showed that rectal sensitivity is quite variable and identified how stress, inflammation and sleep deprivation could enhance sensitivity while hypnosis, relaxation and a new class of drugs that blocked serotonin receptors could diminish it. The latter became an important new way of treating IBS.

Read, N.W. The importance of gut feelings. J. Gastrointestinal Motility 1992; 4:79-81.
Prior, A., Read, N.W. Reduction of rectal sensitivity and postprandial motility by Granisetron, a 5HT3 antagonist, in patients with IBS. Alimentary Pharmacology Therap. 1993; 7: 175-180.
Bergin, A.J., Read, N.W. The effects of sleep deprivation on rectal sensitivity in healthy volunteers. Eur. J. Gastroenterol. Hepatol. 1993; 5(7): 527-532.
Read NW, Gwee KA.(1994) The importance of 5HT3 receptors in the gut. Alimentary Pharmacology and therapeutics. 62; l59-73.
Read N.W. (2000). Rectal Distension: From Sensation to Feeling. (Editorial). Gastroenterology 118 (5): 972-974.

Sensitivity to fat in dyspepsia This work unlined the importance of fat in generating dyspeptic...
Disturbed gastroduodenal motility in duodenal ulcer patients A series of studies conducted by Mr David Kerrigan and...
The Intestinal Regulation of Gastric Emptying A series of studies demonstrated how that the slowing of...