Nick Read » duodenum http://www.nickread.co.uk Thu, 22 Oct 2015 13:29:54 +0000 en hourly 1 http://wordpress.org/?v=3.0.1 Sensitivity to fat in dyspepsia http://www.nickread.co.uk/research/2009/03/sensitivity-to-fat-in-dyspepsia/ http://www.nickread.co.uk/research/2009/03/sensitivity-to-fat-in-dyspepsia/#comments Sun, 01 Mar 2009 09:06:23 +0000 admin http://www.nickread.co.uk/?p=156
  • Rectal Sensitivity Irritable Bowel Syndome (IBS) is characterized by increased sensitivity of...
  • Disturbed gastroduodenal motility in duodenal ulcer patients A series of studies conducted by Mr David Kerrigan and...
  • Anorectal Function The anus is much cleverer than we like to think....
    • ]]>     This work unlined the importance of fat in generating dyspeptic symptoms by demonstrating how duodenal infusions of fat could sensitise the stomach to distension and to motion sickness. These effects could be treated by drugs that acted on cholecystokinin, opiate and serotonin receptors.

    1. Khan, M.I., Read, N.W., Grundy, D. (1993) The effect of varying the rate and pattern of gastric distension upon its sensory perception and motor activity. Am. J. Physiology. 264: G824 –G827.
    2. Barbera, R., Feinle, C., Read, N.W. (1995) Abnormal sensitivity to duodenal lipid infusion in patients with functional dyspepsia. Europ.J.Gastro. Hep. 7 (11):1051-7.
    3. Feinle, C., Grundy, D., Read, N.W. (1995) Fat increases vection induced nausea independent of any changes in gastric emptying. Physiol Behav. 58(6):1159-65.
    4. Barbera, R., Feinle, C., Read, N.W. (1995) Nutrient Specific Modulation of Gastric Mechanosensitivity in patients with functional dyspepsia. American Journal of Physiology. Digestive Diseases & Sciences. 40: 1636-1076.
    5. Feinle, C., D’Amato, M., Read, N.W. (1996) Cholecystokinin-A receptors modulate gastric sensory & motor responses to gastric distention & duodenal lipids. Gastroenterology. 110: 1379-1385.
    6. Feinle C, Read NW. (1996) Ondansetron reduces nausea induced by gastro duodenal stimulation without changing gastric motility. Am. J. Physiol. 271: G59l – 597
    7. Read N.W., Freitag B, Abitbol JL. (l997) Efficacy and safety of the peripheral kappa agonist, fedotozine, versus placebo in the treatment of functional dyspepsia. Gut 4l: 664 – 668
    8. Read N.W. (1999). Functional Dyspepsia: a case of indecision. Gastroenterology (editorial). 116 (3):515 – 520.

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    1. Rectal Sensitivity Irritable Bowel Syndome (IBS) is characterized by increased sensitivity of...
    2. Disturbed gastroduodenal motility in duodenal ulcer patients A series of studies conducted by Mr David Kerrigan and...
    3. Anorectal Function The anus is much cleverer than we like to think....

    ]]>     http://www.nickread.co.uk/research/2009/03/sensitivity-to-fat-in-dyspepsia/feed/ 0     Disturbed gastroduodenal motility in duodenal ulcer patients http://www.nickread.co.uk/research/2009/03/disturbed-gastroduodenal-motility-in-duodenal-ulcer-patients/ http://www.nickread.co.uk/research/2009/03/disturbed-gastroduodenal-motility-in-duodenal-ulcer-patients/#comments Sun, 01 Mar 2009 09:03:31 +0000 admin http://www.nickread.co.uk/?p=153
  • The Intestinal Regulation of Gastric Emptying A series of studies demonstrated how that the slowing of...
  • Sensitivity to fat in dyspepsia This work unlined the importance of fat in generating dyspeptic...
  • Rectal Sensitivity Irritable Bowel Syndome (IBS) is characterized by increased sensitivity of...
    • ]]>     A series of studies conducted by Mr David Kerrigan and using the Dent sleeve demonstrated that acid can get trapped in the duodenal bulb in patients predisposed to duodenal ulceration. This can be prevented by drugs that induce gastroduodenal peristalsis.

    1. Houghton, L.A., Kerrigan, D., Read, N.W. (1990) Effect of intraduodenal infusion of acid on the antro-pyloroduodenal motor unit in human volunteers. J. GI Motility 2 (3): 202-208.
    2. Kerrigan, D.D., Read, N.W., Taylor, M.E., Houghton, L.A., Johnson, A.G. (1989) Duodenal bulb acidity and the natural history of duodenal ulceration. Lancet. (8th July). 2(8654):61-3.
    3. Kerrigan, D.D., Houghton, L.A., Read, N.W., Johnson, A.G., Taylor, M.E. (1991) Disturbed gastroduodenal motility in patients with active and healed duodenal ulceration. Gastroenterology 100 (4): 892-900.
    4. Kerrigan, D.D., Taylor, M.E., Read, N.W., Johnson, A.G. (1993) Acid motility and ulcers: a comparison of cisapride with placebo in the prevention of duodenal ulcer relapse. Gut 1993; 34: 1042-1046.

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    1. The Intestinal Regulation of Gastric Emptying A series of studies demonstrated how that the slowing of...
    2. Sensitivity to fat in dyspepsia This work unlined the importance of fat in generating dyspeptic...
    3. Rectal Sensitivity Irritable Bowel Syndome (IBS) is characterized by increased sensitivity of...

    ]]>     http://www.nickread.co.uk/research/2009/03/disturbed-gastroduodenal-motility-in-duodenal-ulcer-patients/feed/ 0     A method for measuring the activity of the gastropyloroduodenal unit in man http://www.nickread.co.uk/research/2009/03/a-method-for-measuring-the-activity-of-the-gastropyloroduodenal-unit-in-man/ http://www.nickread.co.uk/research/2009/03/a-method-for-measuring-the-activity-of-the-gastropyloroduodenal-unit-in-man/#comments Sun, 01 Mar 2009 09:02:30 +0000 admin http://www.nickread.co.uk/?p=151
  • The Intestinal Regulation of Gastric Emptying A series of studies demonstrated how that the slowing of...
  • The Ileal Brake The observation that that infusion of fat and to a...
  • Disturbed gastroduodenal motility in duodenal ulcer patients A series of studies conducted by Mr David Kerrigan and...
    • ]]>     Dr John Dent from the University of Adelaide had invented the perfused sleeve catheter for measuring the pressures across a mobile sphincter. He incorporated this into a multilumen catheter assembly for recording the contractile activity in the stomach, pylorus and duodenum in human subjects. My experience with measuring transmucosal potential difference allowed this catheter to be positioned accurately at the gastroduodenal junction. On sabbatical to Adelaide and applying this method, we were able to define in detail the normal contractile activity across the pylorus under fed and fasted conditions, and in response to infusion of lipid into the duodenum.

    1. Houghton, L.A., Heddle, R., Maddern, G.J., Read, N.W., Downton, J., Toouli, J., Dent, J. (1988) Motor activity of the gastric antum, pylorus and duodenum under fasted conditions and after a liquid meal. Gastroenterology 94: 1276-1284.
    2. Houghton, L.A., Read, N.W., Heddle, R., Horowitz, N., Collins, P.J., Chatterton, B., Dent, J. (1988) The relationship between the motor activity of the antrum, pylorus and duodenum emptying of a solid-liquid mixed meal. Gastroenterology 94: 1285-1291.
    3. Heddle, R., Dent, J., Read, N.W., Houghton, L.A., Toouli, J., Horowitz, M., Maddern, G.J. and Downton, J. (1988) Antropyloroduodenal motor responses to intraduodenal lipid infusion in healthy volunteers. Am. J. Physiol. 254: G671-G679.

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    2. The Ileal Brake The observation that that infusion of fat and to a...
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